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AbstractSeveral lines of research have shown that the old fashioned model of the brain as a pure digital machine might be fundamentally wrong. Supporting systems are important on modulating and driving neural activity and might contain information we could be currently discarding when analyzing neural responses. A holistic approach might be the key to fully understand processing taking place in the brain: How neurons and accompanying systems interact to convey information using a natively analogue/digital mechanism. First published as manuscript in March 2021.