Signal Transduction (Broché)

Bastien-D Gomperts, Ijsbrand-M Kramer, Peter-E-R Tatham

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  • Academic press

  • Paru le : 01/01/2002
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Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how tells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevante to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signaling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work. Throughout, the authors take the opportunity to confront controversies, to discuss ambiguities and to challenge dogma, while margin notes provide entertaining asides.
    • Signal transduction, origins and personalities
    • First messengers
    • Receptors
    • GTP-bindings proteins and signal transduction
    • Effector enzymes coupled to GTP-binding proteins : adenylyl cyclase and phospholipase C
    • The regulation of visual transduction
    • Calcium and signal transduction
    • Calcium signaling
    • Phosphorylation and dephosphorylation: protenin kinases A and C
    • Growth factors: settings the framework
    • Signalling pathways operated by receptor protein tyrosine kinases
    • Signalling pathways operated by non-receptor protein tyrosine kinases
    • Phosphoinositide 3-kinaeses, protein kinase B and signaling through the insulin receptor
    • Signal transduction to and from adhesion molecules
    • Adhesion molecules and trafficking of leukocytes
    • Signalling through receptor bound protein serine / threonine kinases
    • Protein dephosphorylation and protein phosphorylation
    • Protein domains and signal transduction
  • Date de parution : 01/01/2002
  • Editeur : Academic press
  • ISBN : 0-12-289631-9
  • EAN : 9780122896316
  • Présentation : Broché
  • Nb. de pages : 424 pages
  • Poids : 1.43 Kg
  • Dimensions : 19,5 cm × 25,5 cm × 2,8 cm

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Bastien-D Gomperts et Ijsbrand-M Kramer - Signal Transduction.
Signal Transduction
95,20 €
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