Une pure merveille !
Un roman d'une grande beauté, drôle, fin, extrêmement lumineux sur des sujets difficiles : la perte de
l'être aimé, la dureté de la vie et la tristesse qu'on barricade parfois... Elise franco-japonaise,
orpheline de sa maman veut poser LA question à son père et elle en trouvera le courage au fil des pages,
grâce au retour de sa grand-mère du japon, de sa rencontre avec son extravagante amie Stella..
Ensemble il ne diront plus Sayonara mais Mata Ne !
Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how tells respond to external cues (hormones,...
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Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how tells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevante to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signaling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work. Throughout, the authors take the opportunity to confront controversies, to discuss ambiguities and to challenge dogma, while margin notes provide entertaining asides.
Sommaire
Signal transduction, origins and personalities
First messengers
Receptors
GTP-bindings proteins and signal transduction
Effector enzymes coupled to GTP-binding proteins : adenylyl cyclase and phospholipase C
The regulation of visual transduction
Calcium and signal transduction
Calcium signaling
Phosphorylation and dephosphorylation: protenin kinases A and C
Growth factors: settings the framework
Signalling pathways operated by receptor protein tyrosine kinases
Signalling pathways operated by non-receptor protein tyrosine kinases
Phosphoinositide 3-kinaeses, protein kinase B and signaling through the insulin receptor
Signal transduction to and from adhesion molecules
Adhesion molecules and trafficking of leukocytes
Signalling through receptor bound protein serine / threonine kinases
Protein dephosphorylation and protein phosphorylation