Une pure merveille !
Un roman d'une grande beauté, drôle, fin, extrêmement lumineux sur des sujets difficiles : la perte de
l'être aimé, la dureté de la vie et la tristesse qu'on barricade parfois... Elise franco-japonaise,
orpheline de sa maman veut poser LA question à son père et elle en trouvera le courage au fil des pages,
grâce au retour de sa grand-mère du japon, de sa rencontre avec son extravagante amie Stella..
Ensemble il ne diront plus Sayonara mais Mata Ne !
In this book twenty-seven invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular...
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Résumé
In this book twenty-seven invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.
Sommaire
PATHOGENESIS OF PRION DISEASES
Neurografts to neuroinvasion
Follicular dendritic cells en scrapies pathogenesis
Cellular and sub-cellular localisation of PrP in the Lymphoreticular system of mice and sheep
Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice
Pathogenesis of natural scrapie in sheep
ANIMAL MODELS FOR PRION DISEASES
Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrPc
Analyzing the influence of PrP primary structure on prion pathogenesis en transgenic mice
A single amino acid alteration in murine PrP dramatically alters TSE incubation time
A transgenic model of a familial prion disease
Transgenic models of prion disease
EPIDEMIOLOGY AND DIAGNOSIS OF PRION DISEASES
Surveillance of BSE
Histopathology and immunohistochemistry of human transmissible spongiform encephalopathies (TSEs)
Pathology of variant Creutzfeldt-Jakob disease
Clinical and differantial diagnosis of Creutzfeldt-Jakob disease
Putting prions into focus : application of single molecule detection to the diagnosis of prion diseases
Detection of PrPsc in subclinical BSE with the parrafin-embedded tissue (PET) blot
Sheep and goats : natural and experimental TSEs and factors influencing incidence of disease
Application of Prionics Western blotting procédure K-resistant form of the prion protein using two-site immunometric assays, application to the post-mortem diagnosis of BSE
CHARACTERIZATION OF THE INFECTIOUS AGENT
PrPsc typing by N-terminal sequencing and mass spectrometry
Characterization of BSE and scrapie strains/isolates
Quantitatives traits of prion strains are enciphered in the conformation of the prion protein
STRUCTURE AND FUNCTION OF PrP
Function of PrPc as a copper-binding protein at the synapse
The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations
Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro
PrP CONVERSION
Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs
The use of monoclonal antibody epitopes for tagging PrP in conversion experiments.