Multiple Analyses in Clinical Trials - Fundamentals for Investigators (Relié)

Lemuel-A Moyé

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  • Springer

  • Paru le : 01/01/2003
  • 1 million de livres à découvrir
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One of the most challenging issues for clinical trial investigators, sponsors, and regulatory officials is the interpretation of experimental results that are composed of the results of multiple statistical analyses. These analyses may include the effect of therapy on multiple endpoints, the assessment of a subgroup analysis, and the evaluation of a dose-response relationship in complex mixtures. Multiple Analyses in Clinical Trials: Fundamentals for Investigators is an essentially nonmathematical discussion of the problems posed by the execution of multiple analyses in clinical trials. It concentrates on the rationale for the analyses, the difficulties posed by their interpretation, easily understood solutions, and useful problem sets. This text will help clinical investigators understand multiple analysis procedures and the key issues when designing their own work or reviewing the research of others. This book is written for advanced medical students, clinical investigators at all levels, research groups within the pharmaceutical industry, regulators at the local, state, and federal levels, and biostatisticians. Only a basic background in health care and introductory statistics is required.
    • Fundamentals of clinical trial design
    • Multiple analyses and the random experiment
    • The lure and complexity of multiple analyses
    • Multiple analyses and multiple endpoints
    • Introduction to multiple dependent analyses
    • Introduction to composite endpoints
    • Multiple analyses and composite endpoints
    • Introduction to subgroup analyses
    • Subgroups
    • Multiple analyses and multiple treatment arms
    • Combining multiple analyses
  • Date de parution : 01/01/2003
  • Editeur : Springer
  • Collection : Statistics for Biology and Hea
  • ISBN : 0-387-00727-X
  • EAN : 9780387007274
  • Présentation : Relié
  • Nb. de pages : 436 pages
  • Poids : 0.785 Kg
  • Dimensions : 16,0 cm × 24,0 cm × 2,5 cm

Biographie de Lemuel-A Moyé

Lemuel A. Moyé, M.D., Ph.D., is a physician and Professor of Biostatistics at the University of Texas School of Public Health. He has been Co-Principal Investigator of two multinational clinical trials examining the role of innovative therapy in post myocardial infarction survival (SAVE) and the use of cholesterol-reducing agents in post myocardial infarction survival in patients with normal cholesterol levels (CARE). Professor Moyé has served on multiple advisory committees to the Federal Food and Drug Administration, as a consultant for several major pharmaceutical companies, and as an expert witness. He has authored over one hundred articles in journals, such as the Journal of the American Medical Association, the New England Journal of Medicine, Statistics in Medicine, and Controlled Clinical Trials.

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Multiple Analyses in Clinical Trials. Fundamentals for Investigators
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