Green chemistry, the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances, is a powerful tool in designing safer polymers. By adhering to the principles of green chemistry, manufacturers can produce polymers that are better for the environment, and can do so in an economically sound manner. The Polymer Exemption Rule delineates types of polymers that are expected to be of reduced risk. By following the guidelines contained within the Polymer Exemption Rule, manufacturers may decrease their regulatory requirements while designing polymers that are environmentally benign. This valuable guide approaches the manufacture of polymers from two perspectives, incorporating the principles of green chemistry with the guidance of the Polymer Exemption Rule to design environmentally benign polymers. Designing Safer Polymers is an indispensable working resource for polymer scientists and engineers, as well as corporate decision makers working in the polymer and chemical industries.