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A Simple Guide to Waterhouse-Friderichsen Syndrome, Diagnosis, Treatment and Related Conditions
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- FormatePub
- ISBN978-1-005-90234-6
- EAN9781005902346
- Date de parution01/06/2021
- Protection num.pas de protection
- Infos supplémentairesepub
- ÉditeurC. C. Chamberlane
Résumé
This book describes Waterhouse-Friderichsen Syndrome, Diagnosis and Treatment and Related DiseasesWaterhouse-Friderichsen syndrome (WFS) is a cluster of symptoms happening from the failure of the adrenal glands to function normally as a effect of bleeding into the gland. WFS are caused by serious infection with meningococcus bacteria or other bacteria, such as:1. Group B streptococcus2. Pseudomonas aeruginosa3.
Streptococcus pneumoniae4. Staphylococcus aureusWaterhouse-Friderichsen syndrome was first mentioned in cases of Neisseria meningitidis sepsis. Over the years, several bacterial and viral causes have been linked, which are not limited to:1. Streptococcus pneumonia2. Hemophilus influenzae3. Escherichia coli4. Staphylococcus aureus5. Group A beta-hemolytic Streptococcus6. Capnocytophaga canimorsus7.
Enterobacter cloacae8. Pasteurella multocida9. Plesiomonas shigelloides10. Neisseria gonorrhoeae11. Moraxella duplexBilateral adrenal hemorrhage has also been mentioned with:1. Rickettsia rickettsii2. Bacillus anthracis3. Treponema pallidum4. Legionella pneumophila5. Viral infections such as Cytomegalovirus, Parvovirus B19, Epstein-Barr virus, and Varicella zoster virusIn children who died due to sepsis and bilateral adrenal hemorrhage, Pseudomonas aeruginosa was the most frequent pathogen diagnosed.
N. meningitidis is the most frequent bacteria linked with adrenal hemorrhageOther risk factors linked with WFS are:1. The use of anticoagulants, 2. Thrombocytopenia, 3. Hypercoagulable states as heparin-induced thrombocytopenia, and antiphospholipid syndrome, 4. Trauma to the adrenals, 5. Postoperative state. Trauma was the documented cause of adrenal hemorrhage 2.8% patients.2.1% patients had adrenal hemorrhage linked with anticoagulant therapyAdrenal hemorrhage was not common (5.4%, n=6) as a complication of chronic anticoagulation in patients receiving warfarin alone without antiplatelet therapy.
Symptoms can happen suddenly. They are caused by the bacteria growing (multiplying) inside the body. Symptoms are:1. Fever and chills2. Joint and muscle pain3. Headache4. VomitingOn abdominal examination, abdominal rigidity or rebound tenderness may be evident. WFS linked with meningococcemia typically shows:1. Petechial rash, 2. Disseminated intravascular coagulation, 3. Purpura fulminansThe petechial rash normally forms on the trunk and lower portions of the body but can form over mucous membranes as well.
If the doctor suspects the infection is produced by meningococcus bacteria, other tests are:1. Lumbar puncture to get a sample of spinal fluid for culture2. Skin biopsy and Gram stain test of samplePatients with Waterhouse Friderichsen syndrome manifest with sepsis. A blood sample is taken, and the treatment started instantly before obtaining the results. Antibiotics are given right away to treat the bacterial infection.
Glucocorticoid medicines will also be given to treat any adrenal gland insufficiency. Supportive treatments will be required for other symptoms. Hypoglycemia is treatable by infusing 2 to 4 ml/kg of 25% dextrose as a bolus. TABLE OF CONTENTIntroductionChapter 1 Waterhouse-Friderichsen SyndromeChapter 2 CausesChapter 3 SymptomsChapter 4 DiagnosisChapter 5 TreatmentChapter 6 PrognosisChapter 7 Adrenal HemorrhageChapter 8 Life and Death of an Adrenal GlandEpilogue
Streptococcus pneumoniae4. Staphylococcus aureusWaterhouse-Friderichsen syndrome was first mentioned in cases of Neisseria meningitidis sepsis. Over the years, several bacterial and viral causes have been linked, which are not limited to:1. Streptococcus pneumonia2. Hemophilus influenzae3. Escherichia coli4. Staphylococcus aureus5. Group A beta-hemolytic Streptococcus6. Capnocytophaga canimorsus7.
Enterobacter cloacae8. Pasteurella multocida9. Plesiomonas shigelloides10. Neisseria gonorrhoeae11. Moraxella duplexBilateral adrenal hemorrhage has also been mentioned with:1. Rickettsia rickettsii2. Bacillus anthracis3. Treponema pallidum4. Legionella pneumophila5. Viral infections such as Cytomegalovirus, Parvovirus B19, Epstein-Barr virus, and Varicella zoster virusIn children who died due to sepsis and bilateral adrenal hemorrhage, Pseudomonas aeruginosa was the most frequent pathogen diagnosed.
N. meningitidis is the most frequent bacteria linked with adrenal hemorrhageOther risk factors linked with WFS are:1. The use of anticoagulants, 2. Thrombocytopenia, 3. Hypercoagulable states as heparin-induced thrombocytopenia, and antiphospholipid syndrome, 4. Trauma to the adrenals, 5. Postoperative state. Trauma was the documented cause of adrenal hemorrhage 2.8% patients.2.1% patients had adrenal hemorrhage linked with anticoagulant therapyAdrenal hemorrhage was not common (5.4%, n=6) as a complication of chronic anticoagulation in patients receiving warfarin alone without antiplatelet therapy.
Symptoms can happen suddenly. They are caused by the bacteria growing (multiplying) inside the body. Symptoms are:1. Fever and chills2. Joint and muscle pain3. Headache4. VomitingOn abdominal examination, abdominal rigidity or rebound tenderness may be evident. WFS linked with meningococcemia typically shows:1. Petechial rash, 2. Disseminated intravascular coagulation, 3. Purpura fulminansThe petechial rash normally forms on the trunk and lower portions of the body but can form over mucous membranes as well.
If the doctor suspects the infection is produced by meningococcus bacteria, other tests are:1. Lumbar puncture to get a sample of spinal fluid for culture2. Skin biopsy and Gram stain test of samplePatients with Waterhouse Friderichsen syndrome manifest with sepsis. A blood sample is taken, and the treatment started instantly before obtaining the results. Antibiotics are given right away to treat the bacterial infection.
Glucocorticoid medicines will also be given to treat any adrenal gland insufficiency. Supportive treatments will be required for other symptoms. Hypoglycemia is treatable by infusing 2 to 4 ml/kg of 25% dextrose as a bolus. TABLE OF CONTENTIntroductionChapter 1 Waterhouse-Friderichsen SyndromeChapter 2 CausesChapter 3 SymptomsChapter 4 DiagnosisChapter 5 TreatmentChapter 6 PrognosisChapter 7 Adrenal HemorrhageChapter 8 Life and Death of an Adrenal GlandEpilogue























