Nouveauté
Supercool - The Physics, Mathematics, and Engineering of Cryogenesis
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- FormatePub
- ISBN8235452787
- EAN9798235452787
- Date de parution15/08/2026
- Protection num.pas de protection
- Infos supplémentairesepub
- ÉditeurIoakim Ioakim
Résumé
Master the Physics and Engineering of Macro-Scale CryogenesisFor decades, cryobiology focused successfully on microscopic cell suspensions, leaving macro-scale organ preservation constrained by the destructive limits of ice crystal formation, thermal shock, and vascular collapse. Supercool: The Physics, Mathematics, and Engineering of Cryogenesis bridges the gap between low-temperature physics and advanced biomedical engineering, providing a comprehensive roadmap for achieving stable, ice-free biological stasis.
Written for biosystems engineers, researchers, and students, this authoritative textbook deconstructs the entire engineering lifecycle of advanced bio-preservation. Explore how modern engineering transforms biological stasis from a theoretical challenge into a scalable industrial reality. Key Technical Focus Areas: Deep Sub-Zero Thermodynamics: Master classical nucleation theory, phase equilibria, transient heat conduction via Fourier's law, and latent heat of fusion dynamics.
Vascular Perfusion Physics: Navigate complex fractal microvascular networks, non-Newtonian CPA viscosity profiles, and convective-diffusive transport coupling. Vitrification & Glass Transition Engineering: Optimize critical cooling rates ($q$), manage glass transition kinetics ($T_g$), and leverage high-pressure phase shifts. Fracture Mechanics & Stress Relief: Mitigate thermal stress, differential contraction mismatches, and micro-cracking using macromolecular polymers and isothermal annealing.
Nanoparticle-Assisted Rapid Warming: Defeat the re-warming crisis and prevent devitrification using superparamagnetic iron oxide nanoparticles (SPIONs) and alternating magnetic fields (AMF). Ischemic & Metabolic Preservation: Combat ATP depletion, oxidative stress cascades, and mitochondrial permeability transition pore (mPTP) failure. Post-Thaw Recovery & Biofabrication: Execute automated microfluidic stepwise CPA dilution curves, restore endothelial nitric oxide signaling, and integrate detergent-decellularized ECM scaffolds.
Whether you are designing next-generation organ preservation hardware, optimizing cryogenic biobanking logistics, or exploring the future of regenerative medicine, Supercool provides the rigorous quantitative framework required to conquer biological time and space.
Written for biosystems engineers, researchers, and students, this authoritative textbook deconstructs the entire engineering lifecycle of advanced bio-preservation. Explore how modern engineering transforms biological stasis from a theoretical challenge into a scalable industrial reality. Key Technical Focus Areas: Deep Sub-Zero Thermodynamics: Master classical nucleation theory, phase equilibria, transient heat conduction via Fourier's law, and latent heat of fusion dynamics.
Vascular Perfusion Physics: Navigate complex fractal microvascular networks, non-Newtonian CPA viscosity profiles, and convective-diffusive transport coupling. Vitrification & Glass Transition Engineering: Optimize critical cooling rates ($q$), manage glass transition kinetics ($T_g$), and leverage high-pressure phase shifts. Fracture Mechanics & Stress Relief: Mitigate thermal stress, differential contraction mismatches, and micro-cracking using macromolecular polymers and isothermal annealing.
Nanoparticle-Assisted Rapid Warming: Defeat the re-warming crisis and prevent devitrification using superparamagnetic iron oxide nanoparticles (SPIONs) and alternating magnetic fields (AMF). Ischemic & Metabolic Preservation: Combat ATP depletion, oxidative stress cascades, and mitochondrial permeability transition pore (mPTP) failure. Post-Thaw Recovery & Biofabrication: Execute automated microfluidic stepwise CPA dilution curves, restore endothelial nitric oxide signaling, and integrate detergent-decellularized ECM scaffolds.
Whether you are designing next-generation organ preservation hardware, optimizing cryogenic biobanking logistics, or exploring the future of regenerative medicine, Supercool provides the rigorous quantitative framework required to conquer biological time and space.
