The Nuclear Receptor

Note moyenne 
Hinrich Gronemeyer et Vincent Laudet - .
How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences,... Lire la suite
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Résumé

How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, and structure? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series bas established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'A growing series of excellent manuals' by Molecular Medicine Today, and 'Essential works of reference' by Trends in Biochemical Sciences the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties and biological activity. Meticulously researched and compiled by experts in the field, keeping abreast of developments bas never been so easy! The Nuclear Receptor FactsBook provides up-to-date and comprehensive data on Nuclear Receptors and includes an invaluable guide to their mode of action. Introductory chapters provide information on receptor structure, DNA recognition, agonist and antagonist binding, coregulator interaction, transcription, crosstalks, in vivo functions and evolution. This is followed by entries on each type of receptor, including steroid and thyroid hormone receptors, retinoid and rexinoidreceptors, PPARs, Rev-erbs, RORs, Ecdysone receptor, LXR, FXR, vitamin D receptors, PXR/CAR and related orphans, NGFIB, ERRS, SF1, GCNF1, HNF4, TR2, TLL, and COUP-TFs. Entries provide information on: • Nomenclature and structure • Isolation • DNA binding properties • Ligands • Expression • Target genes • Knockouts • Disease association • Gene structure, promoter and isoforms • Chromosomal location • Amino acid sequences • Key references

Sommaire

    • General organization of nuclear receptors
    • DNA recognition by nuclear receptors
    • Ligand binding
    • Molecular mechanisms of transcriptional regulation
    • RXR subordination in heterodimers
    • Antagonist action
    • Nuclear receptors: platforms for multiple signal integration
    • Deregulation in disease and novel therapeutic targets
    • Genes and evolution

Caractéristiques

  • Date de parution
    24/10/2001
  • Editeur
  • Collection
  • ISBN
    0-12-437735-1
  • EAN
    9780124377356
  • Présentation
    Broché
  • Nb. de pages
    462 pages
  • Poids
    0.84 Kg
  • Dimensions
    15,6 cm × 23,3 cm × 2,5 cm

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116,50 €