Applied Statistical Genetics with R. For Population-based Association Studies
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- Nombre de pages252
- PrésentationBroché
- FormatGrand Format
- Poids0.46 kg
- Dimensions15,5 cm × 23,3 cm × 1,5 cm
- ISBN978-0-387-89553-6
- EAN9780387895536
- Date de parution01/05/2009
- CollectionUse R!
- ÉditeurSpringer
Résumé
Applied Statistical Genetics with R offers a clear and cogent presentation of several fundamental statistical approaches tha researchers from multiple disciplines, including medicine, public health, epidemiology, statistics and computer science, will find useful in exploring this emerging field. Couched in the language of biostatistics, this text can be easily adopted for public health and medical school curricula.
The text covers key genetic data concepts and statistical principles to provide the reader with a strong foundation in methods for candidate gene and genome-wide association studies. These include methods for unobservable haplotypic phase, multiple testing adjustments, and high-dimensional data analysis. Emphasis is on analysis of data arising from studies of unrelated individuals and the potential interplay among genetic factors and more traditional, epidemiological risk factors for disease.
While theoretically rigorous, the analytic techniques are presented at a level that will appeal to researchers and students with limited knowledge of statistical genetics. The text assumes the reader has completed a first course in biostatistics, uses publicly available data sets for illustration, and provides extensive examples using the open source, publicly available statistical software environment R.