McTeague. by Frank Norris

McTeague is an enormously strong but dim-witted former miner now working as a dentist in San Francisco towards the end of the nineteenth century. He falls in love with Trina, one of his patients, and shortly after their engagement she wins a large sum in a lottery. All is well until McTeague is betrayed and they fall into a life of increasing poverty and degradation. This novel is often presented as an example of American naturalism where the behavior and experience of characters are constrained by "nature"-both their own heredity nature, and the broader social environment.
McTeague was published in 1899 as the first of Norris's major novels.