Dark Fangs Rising. Luke Irontree & The Last Vampire War, #1

Killing vampires is Luke Irontree's business, and business is good. Too good. After nearly 2, 000 years, the immortal vampire hunter is exhausted. Alone in a world where everyone he knew and loved is dead, he struggles on because it's all he knows. But when a wave of vampire attacks brings a dark pall over Portland, Luke is the only one who can stop them. The problem is, he let things go too long.
Now he's outnumbered, and the tables have turned - the hunter has become the hunted. After falling into a trap, Luke is rescued by a werewolf and a tough female vampire hunter who want to join forces. However, Luke is too afraid of losing more friends. Luke might not have a choice if he wants to protect his home and survive to tell the tale. Allies are a dangerous risk - both for himself and for them.
Vampire hunting has always been a deadly business. But with the gutters running red with blood, Luke must make the impossible choices or die trying...