Computational analysis of biochemical systems - A practical guide for biochemists and molecular biologists (Broché)

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Eberhard-O Voit

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  • Cambridge University Press

  • Paru le : 01/01/2000
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Throughout the foreseeable future, research in medicine, molecular biology, and biotechnologywill be dominated by scientific advancements resulting from the Human Genome Project. Knowledge of genomes will elucidate disease patterns and promises improved and personalized treatments. Food and drug development will be revolutionized by the focused manipulation of genes and biochemical processes. Researchers will begin to construct metabolic pathways from scratch. A true understanding of genetic and metabolic function and design will crucially depend on mathematical and computational methods for analyzing biochemical systems. It will require new ways of thinking and novel approaches of integrat ve analysis. This book teaches biochemists and molecular biologists in a hands-on fashion the use of modern computational methods for the analysis of complex biomedical systems; a modest mathematical background will suffice. The book begins with representations of biochemical systems, provides guidelines for setting up modess, discusses in detail mathematical and computational methods of parameter estimation and model analysis, and ultimately connects to the modern literature with four detailed case studies. Every step is illustrated with examples and exercises, and is explored with the accompanying software, PLAS. A dedicated Web site featuring color illustrations, further exorcises, research news, as well as resources and links also accompanies this book.
    • Graphical Representation of Biochemical Systems
    • Models of Biochemical Systems
    • From Maps to Equations
    • Computer Simulation
    • Parameter Estimation
    • Analytical Steady-State Evaluation
    • Sensitivity Analysis
    • Case Study 1- Anaerobic Fermentation Pathway in Saccharomyces cerevisiae
    • Case Study 2 - Diagnosis and Refinement of a Model of the Tricarboxylic Acid Cycle in Dictyostelium discoideum
    • Case Study 3 - A Sequence of Models Describing Purine Metabolism
    • Case Study 4 - Algebraic Analysis of the Initial Steps of the Glycolytic-Glycogenolytic Pathway in Perfused Rat Liver
    • Epilogue - Canonical Modeling Beyond Biochemistry
  • Date de parution : 01/01/2000
  • Editeur : Cambridge University Press
  • ISBN : 0-521-78579-0
  • EAN : 9780521785792
  • Présentation : Broché
  • Nb. de pages : 532 pages
  • Poids : 1.005 Kg
  • Dimensions : 18,0 cm × 25,5 cm × 2,5 cm

Biographie d'Eberhard-O Voit

Eberhard O. Voit is Professor of Biometry in the Department of Biometry and Epidemiology at the Medical University of South Carolina. PLAS was created by Antônio E. N. Ferreira, Instructor in the Department of Chemistry and Biochemistry at the University of Lisbon, Portugal.

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