Une pure merveille !
Un roman d'une grande beauté, drôle, fin, extrêmement lumineux sur des sujets difficiles : la perte de
l'être aimé, la dureté de la vie et la tristesse qu'on barricade parfois... Elise franco-japonaise,
orpheline de sa maman veut poser LA question à son père et elle en trouvera le courage au fil des pages,
grâce au retour de sa grand-mère du japon, de sa rencontre avec son extravagante amie Stella..
Ensemble il ne diront plus Sayonara mais Mata Ne !
An immensely complex network of interactions between multiple cell types and cytokines regulates the immune system. Ligand binding to antigen-specific,...
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Résumé
An immensely complex network of interactions between multiple cell types and cytokines regulates the immune system. Ligand binding to antigen-specific, Fc, or cytokine receptors initiates differentiation, activation and proliferation of multiple immune system cell lineages. These activating pathways are counteracted by inhibitory receptors. In the past two decades, considerable work on mechanistic and functional details of such intracellular signaling pathways has led to the realization that an excess of stimulatory/positive signals as well as a deficiency in inhibitory/negative signals can both result in a hyperactive immune system leading to autoimmunity. The chapters included in this volume represent but a few examples of the close link between aberrant signaling pathways and autoimmune diseases. They cover a variety of cells (T, B and myeloid/monocytic cells), receptors (for antigen, Fc and cytokines) and intracellular signaling molecules (kinases, phosphatases, adapters and transcription factors) in the immune system. This book brings together clinical and experimental aspects of autoimmune disease and the fundamental science of intracellular signaling pathways. Therefore, it should be of interest to clinical investigators of autoimmune diseases as well as to basic immunologists and cell biologists interested in the molecular basis of signal transduction in the immune system.
Sommaire
Regulation of Signal Transduction by the Fcgamma Receptor Family Members and Their Involvement in Autoimmunity
The Role of TNF/TNFR in Organ-Specific and Systemic Autoimmunity: Implications for the Design of Optimized `Anti-TNF' Therapies
CD40 Signaling and Autoimmunity
TGF-beta: Receptors, Signaling Pathway and Autoimmunity
Interleukin-2 Signaling and the Maintenance of Self-Tolerance
Role of the B7-CD28/CTLA-4 Pathway in Autoimmune Disease
Abnormal T Lymphocyte Signal Transduction in Systemic Lupus Erythematosus
Lyn/CD22/SHP-1 and Their Importance in Autoimmunity
Regulation of Immune Responses by E3 Ubiquitin-Protein Ligases
Keeping the C-Tell Immune Response in Balance: Role of Protein Tyrosine Phosphatases in Autoimmunity