This fifth edition of the most widely used and respected reference manual for the organic chemistry laboratory incorporated important new reactions and techniques now available to the organic chemist, and retains many of the standard procedures of previous editions. These are all set within a theoretical framework based on developments in the strategy and methodology of organic synthesis, reflecting the fundamental changes in approach to the subject made during the last decade. New to this edition: An introductory chapter on the structural and theoretical principles required when designing a synthesis; The disconnection or synthon approach now integrated into the text, and the principles of retrosynthetic analysis applied to relevant aliphatic, aromatic, alicyclic and heterocyclic compounds; Synthesis methodology is expanded to cover a range of new reagents, including oxidants and reductants, reagents for asymmetric synthesis, and those derived from lithium, boron, silicon, phosphorus and sulphur; Recent developments in reaction techniques which includes: handling of air-sensitive and moisture-sensitive compounds, new chromatographic procedures, phase transfer catalysis, and solid support reagents; Over 100 experiments selected from the literature to illustrate new reagents and techniques, and the operation of protection, selectivity and control in synthesis; A more detailed treatment of carbon-13 n.m.r spectroscopy, and the interpretation of spectroscopic data for many of the synthesised compounds. This completely updated edition of Vogel, as with previous revisions over the past forty years, will continue to be an indispensable text for organic chemists throughout their undergraduate, postgraduate and subsequent careers. The late Arthur I.Vogel was formerly Head of the Chemistry Department at Woolwich (now Thames) Polytechnic, London.